Home > Clinical question: What are the benefits and harms of naloxone in opiate‐exposed newborn infants?

Davies, Mark [The Cochrane Library] . (2015) Clinical question: What are the benefits and harms of naloxone in opiate‐exposed newborn infants? London: Wiley. Cochrane Clinical Answers

URL: https://www.cochranelibrary.com/cca/doi/10.1002/cc...

There is no randomized controlled trial evidence that giving naloxone to all babies who have been exposed to maternal opioids (for analgesia in labour) improves any clinically meaningful outcomes (such as need for neonatal intensive or special care, time to establish feeding, neonatal seizures) over placebo or no treatment; all the outcomes assessed in the trials were proxy outcomes.

Some of the nine trials, enrolling 316 newborn infants in total, did report improvements in measures of respiratory function (expired carbon dioxide and alveolar ventilation); however, these outcomes are of little clinical relevance.

There remains the serious theoretical risk of harm to infants at risk of neonatal abstinence syndrome secondary to long‐term in utero exposure to opioids (either illicit or for chronic pain). Naloxone given to such infants may cause acute withdrawal and seizures.


Item Type:Evidence resource
Publication Type:Guideline
Drug Type:Opioid
Intervention Type:AOD disorder, AOD disorder drug therapy, AOD disorder treatment method, AOD disorder harm reduction
Source:The Cochrane Library
Date:31 March 2015
Publisher:Wiley
Place of Publication:London
EndNote:View
Subjects:B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product > Naloxone
G Health and disease > Substance use disorder > Drug use > Drug withdrawal syndrome
G Health and disease > Disorder by cause > Developmental disorder
HJ Treatment method > Substance disorder treatment method > Substance disorder drug therapy
J Health care, prevention and rehabilitation > Substance use prevention > Substance use harm reduction
J Health care, prevention and rehabilitation > Patient care management
N Communication, information and education > Recommendations or guidelines > Practice / clinical guidelines
T Demographic characteristics > Child of substance user

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