Home > Medications for opioid use disorder.

Substance Abuse and Mental Health Services Administration. (2021) Medications for opioid use disorder. Rockville, MD: Substance Abuse and Mental Health Services Administration. Treatment Improvement Protocol (TIP) series 63 publication no. PEP21-02-01-002.

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External website: https://store.samhsa.gov/product/SMA18-5063FULLDOC


This Treatment Improvement Protocol (TIP) reviews the use of the three Food and Drug Administration (FDA)-approved medications used to treat opioid use disorder (OUD)—methadone, naltrexone, and buprenorphine—and the other strategies and services needed to support recovery for people with OUD.

Audience: people with substance use or abuse problems as audience, public health professionals, professional care providers, policymakers, family & advocates, parents & caregivers. 

Executive Summary
For healthcare and addiction professionals, policymakers, patients, and families

Part 1: Introduction to Medications for Opioid Use Disorder Treatment
For healthcare and addiction professionals, policymakers, patients, and families

Part 2: Addressing Opioid Use Disorder in General Medical Settings
For healthcare professionals

Part 3: Medications for Opioid Use Disorder
For healthcare professionals

Part 4: Bringing Together Addiction Treatment Counselors, Clients, and Healthcare Professionals
For healthcare and addiction professionals

Part 5: Resources Related to Medications for Opioid Use Disorder
For healthcare and addiction professionals, policymakers, patients, and families

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