Home > Survival from alcoholic hepatitis has not improved over time.

Hughes, Emily and Hopkins, Laurence and Parker, Richard (2018) Survival from alcoholic hepatitis has not improved over time. PLoS ONE , 13 , (2) , e0192393.

URL: http://journals.plos.org/plosone/article?id=10.137...

Purpose/Background: We aimed to describe changes in survival in alcoholic hepatitis (AH) over time by examining published data.

Results: After review of the literature search results, 77 studies published between 1971 and 2016 were analysed, which included data from a total of 8,184 patients. Overall mortality from AH was 26% at 28 days, 29% at 90 days and 44% at 180 days after admission. No changes in mortality over time were observed in univariable analysis at 28 days or 90 days after admission (Pearson correlation r -0.216, p = 0.098, and r 0.121 p = 0.503 respectively). A small but statistically significant increase in mortality was seen in 180-day mortality (r 0.461 p = 0.036). However, after meta-regression to adjust for other factors associated with mortality at each time point, no changes in mortality were seen. Sub-group analysis did not reveal any changes in mortality over time in different study types, or when only biopsy-proven or severe disease were considered.

Conclusion: There has been no improvement in mortality from AH. This is not explained by changes in severity of disease. This emphasises the urgent need for effective treatments for this alcoholic hepatitis.

Item Type:Article
Date:February 2018
Page Range:e0192393
Publisher:Public Library of Science
Subjects:A Substance use, abuse, and dependence > Effects and consequences
B Substances > Alcohol
G Health and disease > State of health > Physical health
G Health and disease > Disorder by cause > Communicable disease
G Health and disease > Digestive system disorder > Liver disorder > Alcoholic hepatitis
P Demography, epidemiology, and history > Population dynamics > Substance related mortality / death

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