Home > Effectiveness of injectable extended-release naltrexone vs daily buprenorphine–naloxone for opioid dependence: A randomized clinical noninferiority trial.

[Drug and Alcohol Findings] (2018) Effectiveness of injectable extended-release naltrexone vs daily buprenorphine–naloxone for opioid dependence: A randomized clinical noninferiority trial. London: Drug and Alcohol Findings. Drug and Alcohol Findings Bulletin (15 March 2018) 5 p.

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URL: http://findings.org.uk/PHP/dl.php?file=Tanum_L_1.t...

Key points from summary and commentary
A novel study testing the relative effectiveness of injections of extended-release naltrexone and a daily combination of oral buprenorphine hydrochloride and naloxone hydrochloride for maintaining abstinence from heroin and other opioids.

Treatment with extended-release naltrexone was found no less effective than buprenorphine–naloxone in terms of retaining patients in treatment, reducing the number of days of injecting and craving for opioids, and reducing the use of heroin, and other illicit drugs.

The authors concluded that maintaining short-term abstinence with extended-release naltrexone should be considered an “equal” medication-assisted treatment alternative to buprenorphine-naloxone for opioid-dependent individuals


Item Type:Evidence resource
Drug Type:Opioid
Intervention Type:AOD disorder drug therapy, AOD disorder treatment method
Source:Drug and Alcohol Findings
Date:March 2018
Pages:5 p.
Publisher:Drug and Alcohol Findings
Place of Publication:London
Number:15 March 2018
EndNote:View
Subjects:B Substances > Opioids (opiates)
B Substances > Opioids (opiates) > Opioid product > Naloxone
B Substances > Opioids (opiates) > Opioid product > Naltrexone
B Substances > Opioids (opiates) > Opioid product > Buprenorphine / Suboxone
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
HJ Treatment method > Treatment outcome

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