This report presents an overview of trends in the drugs situation in Ireland over a 10 year period. The report analyses the most recent data available with respect to the five European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) key indicators (prevalence of drug use, high risk drug use, treatment demand, drug-related deaths and mortality and drug-related infectious diseases) as well as drug-related crime and supply. Where data is available, trends under these six headings since 2005 are reported. In addition to presentation of national trends this reported includes additional evidence looking at trends in data relating to specific sub-populations including people who inject drugs, prisoners, homeless individuals, sex workers and the Travelling community.