Table of Contents
Introduction p.9
1. Substance identification p.12
2. Botany and chemistry p.14
3. Ease of convertibility into controlled substances p.19
4. General pharmacology, including pharmacokinetics and pharmacodynamics p.19
5. Experimental toxicology p.25
6. Clinical toxicology and adverse reactions in humans p.28
7. Dependence potential p.32
8. Therapeutic applications and extent of therapeutic use p.36
9. Listing on the WHO Model List of Essential Medicines p.40
10. Marketing authorizations (as a medicine) p.40
11. Industrial and other use p.41
12. Epidemiology of non-medical use and dependence p.42
13. Nature and magnitude of public health problems related to non-medical use and dependence.. p.43
14. Licit production, consumption and international trade p.43
15. Illicit production and traffic, and related information p.45
16. Current international controls and their impact p.46
17. Current and past national controls p.49
18. Other medical and scientific matters relevant for a recommendation on the scheduling of the substance p.51