Home > Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort.

Reininghaus, Ulrich and Dutta, Rina and Dazzan, Paola and Doody, Gillian A and Fearon, Paul and Lappin, Julia and Heslin, Margaret and Onyejiaka, Adanna and Donoghue, Kim and Lomas, Ben and Kirkbride, James B and Murray, Robin M and Croudace, Tim and Morgan, Craig and Jones, Peter B . (2015) Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort. Oxford. Schizophrenia Bulletin, 41 (3)

URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC439368...

The excess mortality in people with psychotic disorders is a major public health concern, but little is known about the clinical and social risk factors which may predict this health inequality and help inform preventative strategies.

We aimed to investigate mortality in a large epidemiologically characterized cohort of individuals with first-episode psychosis compared with the general population and to determine clinical and social risk factors for premature death. All 557 individuals with first-episode psychosis initially identified in 2 areas (Southeast London and Nottinghamshire, United Kingdom) were traced over a 10-year period in the ӔSOP-10 study. Compared with the general population, all-cause (standardized mortality ratio, natural-cause and unnatural-cause mortality was very high. Illicit drug use was associated with an increased risk of all-cause mortality. Risk of natural-cause mortality increased with a longer time to first remission. Family involvement at first contact strongly reduced risk of unnatural-cause mortality.

Our findings suggest that the mortality gap in people with psychotic disorders remains huge and may be wider for unnatural-cause mortality than previously reported. Efforts should now focus on further understanding and targeting these tractable clinical and social risk factors of excess mortality. Early intervention and dual diagnosis services may play a key role in achieving more rapid remission and carer involvement and addressing substance use problems to reduce excess mortality in psychosis.


Item Type:Evidence resource
Publication Type:Review
Drug Type:Alcohol or other drugs in general
Intervention Type:AOD disorder, AOD disorder harm reduction
Date:May 2015
Page Range:pp. 664-73
Publisher:Oxford
Volume:41
Number:3
EndNote:View
Subjects:G Health and disease > State of health > Mental health
J Health care, prevention and rehabilitation > Risk and protective factors > Risk factors
J Health care, prevention and rehabilitation > Care by type of problem > Mental health care
P Demography, epidemiology, and history > Population dynamics > Substance related mortality / death
VA Geographic area > Europe > United Kingdom

Repository Staff Only: item control page