Home > Liver transplant associated with paracetamol overdose: results from the seven-country SALT study.

Gulmez, Sinem Ezgi and Larrey, Dominique and Pageaux, Georges-Philippe and Bernuau, Jacques and Bissoli, Franco and Horsmans, Yves and Thorburn, Douglas and McCormick, P Aiden and Stricker, Bruno and Toussi, Massoud and Lignot-Maleyran, Séverine and Micon, Sophie and Hamoud, Fatima and Lassalle, Régis and Jové, Jérémy and Blin, Patrick and Moore, Nicholas (2015) Liver transplant associated with paracetamol overdose: results from the seven-country SALT study. British Journal of Clinical Pharmacology , 80 , (3) , pp. 599-606.

All adult overdose-related acute liver failure leading to registration for transplantation (ALFT), with or without suicidal intent, in France, Greece, Ireland, Italy, the Netherlands, Portugal and the UK between 2005 and 2007 were identified from liver transplant registries and hospital records. These were compared with whole-country and per capita use of paracetamol.

Conclusions: Paracetamol overdose was found to represent one-sixth of all-cause ALFT. There was a 50-fold difference in Europe in the rates of paracetamol overdose ALFT, and a 200-fold difference per million inhabitants.


Item Type:Article
Date:2015
Page Range:pp. 599-606
Publisher:Wiley
Volume:80
Number:3
EndNote:View
Related URLs:
Subjects:E Concepts in biomedical areas > Substance by legal status > Over the counter drug (medicine / medication)
F Concepts in psychology > Specific attitude and behaviour > self-destructive behaviour > suicidal behaviour / suicide
G Health and disease > Substance use disorder > Drug use > Drug intoxication > Poisoning (overdose)
G Health and disease > Digestive system disorder > Liver disorder
J Health care, prevention and rehabilitation > Risk and protective factors > Risk factors
VA Geographic area > Europe
VA Geographic area > Europe > Ireland

Click here to request a copy of this literature (must be logged in)

Repository Staff Only: item control page