Home > Universal antenatal screening for Hepatitis C.

Lambert, J and Jackson, V and Coulter-Smith, S and Brennan, M and Geary, Michael and Kelleher, TB and O'Reilly, M and Grundy, K and Sammon, M and Cafferkey, MT (2013) Universal antenatal screening for Hepatitis C. Irish Medical Journal , 106 , (5) , pp. 136-139.

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The aims of this study were to pilot universal antenatal HCV screening and to determine the true seroprevalence of HCV infection in an unselected antenatal population. A risk assessment questionnaire for HCV infection was applied to all women booking for antenatal care over a 1-year period. In addition the prevalence of anti-HCV antibody positive serology in this population was determined. Over the course of the year, 9121 women booked for antenatal care at the Rotunda and 8976 women agreed to take part in the study, representing an uptake of 98.4%. 78 (0.9%) women were diagnosed as anti-HCV positive, the majority of whom were Irish (60.3%) or from Eastern Europe (24.4%). 73% of anti-HCV positive women reported one or more known risk factor with tattooing and a history of drug abuse the most commonly reported. 27% (n=21) of anti-HCV positive women had no identifiable risk factors. Due to selective screening, seroprevalence of HCV is impossible to accurately calculate. However the universal screening applied here and the high uptake of testing has allowed the prevalence of anti-HCV among our antenatal population to be calculated at 0.9%. A significant proportion (27%) of anti-HCV positive women in this study reported no epidemiological risk factors at the time of booking and so were identified only as a result of universal screening. This provides persuasive evidence for the inclusion of HCV testing with routine antenatal screening or at a minimum highlights the need for ongoing review of selective screening criteria.


Item Type:Article
Date:2013
Page Range:pp. 136-139
Publisher:Irish Medical Organisation
Volume:106
Number:5
EndNote:View
Accession Number:HRB (Electronic Only)
Subjects:HA Screening, identification, and diagnostic method > Medical screening and diagnostic method
G Health and disease > Disorder by cause > Communicable disease > Hepatitis C
T Demographic characteristics > Mother
T Demographic characteristics > Person who injects drugs (Intravenous / injecting)
VA Geographic area > Europe > Ireland
E Concepts in biomedical areas > Pregnancy
T Demographic characteristics > Child of person who uses substances
A Substance use, abuse, and dependence > Effects and consequences

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