Home > Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes - a prospective cohort study.

Murphy, Deidre J and Mullaly, Aoife and Cleary, Brian J and Fahey, Tom and Barry, Joseph (2013) Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes - a prospective cohort study. BMC Pregnancy and Childbirth , 13 , (8) .

URL: http://www.biomedcentral.com/1471-2393/13/8

Background: There has been limited research addressing whether behavioural change in relation to alcohol exposure in pregnancy results in better perinatal outcomes.

Methods: A cohort study of 6725 women who booked for antenatal care and delivered in a large urban teaching hospital in 2010–2011. A detailed history of alcohol consumption pre-pregnancy and during early pregnancy was recorded at the first antenatal visit with follow-up of the mother and infant until discharge following birth. Adverse perinatal outcomes were compared for ‘non-drinkers’, ‘ex drinkers’ and ‘current drinkers’.

Results: Of the 6017 (90%) women who reported alcohol consumption prior to pregnancy 3325 (55%) engaged in binge drinking and 266 (4.4%) consumed more than 14 units on average per week. At the time of booking 5649 (94%) women were ex-drinkers and of the 368 women who continued to drink 338 (92%) had a low intake (0–5 units per week), 30 (8%) an excess intake (6-20+ units per week) and 93 (25%) reported at least one episode of binge drinking. Factors associated with continuing to drink in early pregnancy included older maternal age (30–39 years), (OR 1.6; 95% CI 1.3 to 1.8), Irish nationality (OR 3.1; 95% CI 2.2 to 4.3) and smoking (OR 2.6; 95% CI 1.9 to 3.5).
Ex-drinkers had similar perinatal outcomes to non-drinkers. Compared to non-drinkers current drinking was associated with an increased risk of intrauterine growth restriction (IUGR) (13% versus 19%, crude OR 1.6; 95% CI 1.1 to 2.2, adjusted OR 1.2; 95% CI 0.8 to 1.8). The greatest risk of IUGR was among women who continued to both drink and smoke, (9% versus 32%, crude OR 4.8; 95% CI 3.3 to 7.0, adjusted OR 4.5; 95% CI 3.1 to 6.7).

Conclusions: Public Health campaigns need to emphasise the potential health gains of abstaining from both alcohol and smoking in pregnancy.


Item Type:Article
Date:2013
Publisher:BioMed Central Ltd
Volume:13
Number:8
EndNote:View
Accession Number:HRB (Available)
Subjects:E Concepts in biomedical areas > Pregnancy
VA Geographic area > Europe > Ireland
T Demographic characteristics > Pregnant woman
A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption
E Concepts in biomedical areas > Pregnancy > Reproductive effects of substance use

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