Home > Adolescent impulsivity phenotypes characterized by distinct brain networks.

the IMAGEN Consortium. Whelan, Robert and Conrod, Patricia and Poline, Jean-Baptiste and Lourdusamy, Anbarasu and Banaschewski, Tobias and Barker, Gareth J and Bellgrove, MA and Buchel, Christian and Byrne, Mark and Cummins, Tarrant DA and Fauth-Bühler, Mira and Flor, Herta and Gallinat, Jurgen and Heinz, Andreas and Ittermann, Bernd and Mann, Karl and Martinot, Jean-Luc and Lalor, Edmund C and Lathrop, Mark and Loth, Eva and Nees, Frauke and Paus, Tomas and Rietschel, Marcella and Smolka, Michael N and Spanagel, Rainer and Stephens, David N and Struve, Maren and Thyreau, Benjamin and Vollstaedt-Klein, Sabine and Robins, Trevor W and Schumann, Gunter and Garavan, Hugh (2012) Adolescent impulsivity phenotypes characterized by distinct brain networks. Nature Neuroscience , 15 , (6) , pp. 920-925.

URL: http://www.nature.com/neuro/index.html

The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.


Item Type:Article
Date:2012
Page Range:pp. 920-925
Publisher:Nature Publishing Group
Corporate Creators:the IMAGEN Consortium
Volume:15
Number:6
EndNote:View
Accession Number:HRB (Other)
Subjects:A Substance use, abuse, and dependence > Prevalence > Problem substance use
T Demographic characteristics > Adolescent / youth (teenager / young person)
VA Geographic area > International aspects
A Substance use, abuse, and dependence > Effects and consequences

Click here to request a copy of this literature (must be logged in)

Repository Staff Only: item control page