Home > Patterns of alcohol consumption and ischaemic heart disease in culturally divergent countries: the Prospective Epidemiological Study of Myocardial Infarction (PRIME).

Ruidavets, Jean-Bernard and Ducimetière, Pierre and Montaye, Michele and Haas, Bernadette and Bingham, Annie and Yarnell, John D and Amouyel, Philippe and Arveiler, Dominique and Kee, Frank and Bongard, Vanina and Ferrières, Jean (2010) Patterns of alcohol consumption and ischaemic heart disease in culturally divergent countries: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). British Medical Journal , 341 , (c6077) .

URL: http://www.bmj.com/content/341/bmj.c6077

Objective: To investigate the effect of alcohol intake patterns on ischaemic heart disease in two countries with contrasting lifestyles, Northern Ireland and France.

Results: A total of 2405 men from Belfast and 7373 men from the French centres were included in the analyses, 1456 (60.5%) and 6679 (90.6%) of whom reported drinking alcohol at least once a week, respectively. Among drinkers, 12% (173/1456) of men in Belfast drank alcohol every day compared with 75% (5008/6679) of men in France. Mean alcohol consumption was 22.1 g/day in Belfast and 32.8 g/day in France.

Binge drinkers comprised 9.4% (227/2405) and 0.5% (33/7373) of the Belfast and France samples, respectively. A total of 683 (7.0%) of the 9778 participants experienced ischaemic heart disease events during the 10 year follow-up: 322 (3.3%) hard coronary events and 361 (3.7%) angina events. Annual incidence of hard coronary events per 1000 person years was 5.63 (95% confidence interval 4.69 to 6.69) in Belfast and 2.78 (95% CI 2.41 to 3.20) in France. After multivariate adjustment for classic cardiovascular risk factors and centre, the hazard ratio for hard coronary events compared with regular drinkers was 1.97 (95% CI 1.21 to 3.22) for binge drinkers, 2.03 (95% CI 1.41 to 2.94) for never drinkers, and 1.57 (95% CI 1.11 to 2.21) for former drinkers for the entire cohort. The hazard ratio for hard coronary events in Belfast compared with in France was 1.76 (95% CI 1.37 to 2.67) before adjustment, and 1.09 (95% CI 0.79 to 1.50) after adjustment for alcohol patterns and wine drinking. Only wine drinking was associated with a lower risk of hard coronary events, irrespective of the country.

Conclusions: Regular and moderate alcohol intake throughout the week, the typical pattern in middle aged men in France, is associated with a low risk of ischaemic heart disease, whereas the binge drinking pattern more prevalent in Belfast confers a higher risk.

 

Item Type:Article
Date:November 2010
Publisher:BMJ Publishing
Volume:341
Number:c6077
EndNote:View
Accession Number:HRB (Electronic Only)
Subjects:A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption > Binge / risky drinking
A Substance use, abuse, and dependence > Prevalence > Substance use behaviour > Alcohol consumption
A Substance use, abuse, and dependence > Effects and consequences
B Substances > Alcohol
G Health and disease > State of health > Physical health
G Health and disease > Substance use disorder > Alcohol use
G Health and disease > Cardiovascular / Heart disorder
R Research > Type of research study > Research involving two or more groups > Cross-cultural study
VA Geographic area > Europe > Northern Ireland
VA Geographic area > Europe > France

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