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Home > Evidence of increased activation underlying cognitive control in ecstasy and cannabis users.

Roberts, Gloria and Garavan, Hugh (2010) Evidence of increased activation underlying cognitive control in ecstasy and cannabis users. NeuroImage, 52, (2), pp. 429-435. https://doi.org/10.1016/j.neuroimage.2010.04.192.

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External website: http://www.tara.tcd.ie/handle/2262/40204

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The aim of this study was to investigate brain activation during response inhibition and performance monitoring in current recreational drug users who predominantely used ecstasy. Twenty drug users (ten female) and twenty healthy controls were scanned during performance of a response inhibition GO/NOGO task using functional magnetic resonance imaging. No performance deficits were evident. However, the drug user group revealed elevated frontal and parietal BOLD response during successful inhibitions, and temporal, frontal, and cingulate hyperactivity during commision errors. In addition, the users showed reduced deactivation in the default-mode network during task performance. Whether contributing to or arising from drug use, these results reveal dysregulation in brain regions subserving cognitive control and default mode processes in current recreational drug users mirroring effects previously observed for “harder” drugs of abuse.


Item Type
Article
Publication Type
Irish-related, Open Access, Article
Drug Type
Cannabis, CNS stimulants
Date
2010
Identification #
https://doi.org/10.1016/j.neuroimage.2010.04.192
Page Range
pp. 429-435
Publisher
Elsevier Science
Volume
52
Number
2
EndNote
Accession Number
HRB (Electronic Only)
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