Home > Impact of persistent substance misuse on 1-year outcome in first-episode psychosis.

Turkington, Aidan and Mulholland, Ciaran C and Rushe, Teresa M and Anderson, Rick and McCaul, Rosalind and Barrett, Suzanne and Barr, Ruth S and Cooper, Stephen J (2009) Impact of persistent substance misuse on 1-year outcome in first-episode psychosis. British Journal of Psychiatry , 195 , (3) , pp. 242-248.

URL: http://bjp.rcpsych.org/content/195/3/242.full

Background: Substance misuse is a common comorbid problem in people presenting with first-episode psychosis and is associated with a poor short-term outcome.

Aims: The aim of this study is to examine differences in baseline characteristics and 1-year outcome between individuals with first-episode psychosis who have never misused substances, those who stop misusing substances after initial presentation and those who persistently misuse substances over the 1-year assessment period.

Method: Patients were recruited to the Northern Ireland First Episode Psychosis Study (n = 272). Clinical assessments were performed at baseline and at 1 year (n = 194) and data were collected from the case notes.

Results: Individuals with persistent substance misuse had more severe depression, more positive symptoms, poorer functional outcome and greater rates of relapse at 1 year than those who stopped and those who had never misused substances. There were no differences in outcome between people who had never misused substances and those who stopped misusing after presentation.

Conclusions: These results support assertive intervention targeted at comorbid substance misuse in individuals


Item Type:Article
Date:September 2009
Page Range:pp. 242-248
Publisher:Royal College of Psychiatrists
Volume:195
Number:3
EndNote:View
Accession Number:HRB (Not in collection)
Subjects:G Health and disease > State of health > Mental health
HJ Treatment method > Treatment outcome
J Health care, prevention and rehabilitation > Care by type of problem > Mental health care
VA Geographic area > Europe > Northern Ireland
G Health and disease > Substance related disorder > Substance related mental disorder
G Health and disease > Substance related disorder > Dual diagnosis (comorbidity)
A Substance use, abuse, and dependence > Effects and consequences

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