Skip Page Header

Home > Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task.

Roberts, Gloria and Nestor, Liam and Garavan, Hugh (2009) Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task. Brain Research , 1292 , pp. 71-81.

URL: http://www.tara.tcd.ie/handle/2262/33427

It has been consistently shown that ecstasy users display impairments in learning and memory performance. In addition, working memory processing in ecstasy users has been shown to be associated with neural alterations in hippocampal and/or cortical regions as measured by functional magnetic resonance imaging (fMRI).

Using functional imaging and a face-learning task, we investigated neural correlates of encoding and recalling face-name associations in 20 recreational drug users whose predominant drug use was ecstasy and 20 controls.

Ecstasy users performed significantly worse in learning and memory compared to controls and cannabis users.

In both ecstasy and cannabis groups brain activation was decreased in the right medial frontal gyrus, left parahippocampal gyrus, left dorsal cingulate gyrus, and left caudate. These results elucidated ecstasy-related deficits, only some of which might be attributed to cannabis use. These ecstasy-specific effects may be related to the vulnerability of isocortical and allocortical regions to the neurotoxic effects of ecstasy.

 

Item Type
Article
Date
2009
Page Range
pp. 71-81
Publisher
Elsevier Science
Volume
1292
Notes
A PDF file of an unedited manuscript, accepted for publication, is available from the Trinity College Dublin research repository, TARA - http://webird.tcd.ie/handle/2262/33427
EndNote
Accession Number
HRB (Not in collection)
Related URLs

Repository Staff Only: item control page