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Home > Methadone induced torsade de pointes in a patient receiving antiretroviral therapy.

Falconer, M and Molloy, D and Ingerhaug, J and Barry, Michael (2007) Methadone induced torsade de pointes in a patient receiving antiretroviral therapy. Irish Medical Journal , 100 , (10) , pp. 631-632.

URL: http://archive.imj.ie//ViewArticleDetails.aspx?Con...

Adverse drug reactions account for approximately 5% of acute medical admissions. A 34-year-old male patient receiving antiretroviral therapy, methadone and flurazepam presented to the Emergency Room following collapse with associated loss of consciousness. Cardiac monitoring demonstrated marked Q-T prolongation followed by the cardiac arrhythmia, torsade de pointes. The patient made a full recovery following withdrawal of the antiretroviral therapy and a reduction in methadone dose. Methadone is a recognised cause of this potentially fatal cardiac arrhythmia which is more likely to occur when methadone metabolism is inhibited by drugs such as HIV protease inhibitors


Item Type
Article
Date
2007
Page Range
pp. 631-632
Publisher
Irish Medical Organisation
Volume
100
Number
10
EndNote
Accession Number
HRB 4328 (Available)
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