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Home > Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish affected sib pair study of alcohol dependence.

Walsh, Dermot and Kuo, Po-Hsiu and Riley, Brien P and Sullivan, Patrick F and Vittum, Jen and Patterson, Diana G and Thiselton, Dawn L and Oord, Edwin J van den and Kendler, Kenneth S and Prescott, Carol A and Kalsi, Gursharan and Vladimirov, V and Wormley, B and Grotewiel, MS (2006) Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish affected sib pair study of alcohol dependence. Molecular Psychiatry , 11 , (11) , pp. 1025-1031.

Because tolerance is an important aspect of alcohol dependence (AD) in humans, recent evidence showing that the Drosophila gene hang is critically involved in the development of alcohol tolerance in the fly suggests that variation in related human loci might be important in the etiology of alcohol-related disorders.

The orthology of hang in mammals is complex, but a number of human gene products (including ZNF699) with similar levels of amino-acid identity (18-26%) and similarity (30-41%), are consistently identified as the best matches with the translated hang sequence. We tested for association between the dichotomous clinical phenotype of alcohol dependence and seven single nucleotide polymorphisms (SNPs) in ZNF699 in our sample of 565 genetically independent cases and 496 siblings diagnosed with AD, and 609 controls.

In analyses of genetically independent cases and controls, four of the seven single markers show strong evidence for association with AD (0.00003


Item Type
Article
Date
2006
Page Range
pp. 1025-1031
Volume
11
Number
11
Keywords
alcohol dependence, biological AOD tolerance, Drosophila, genome, Ireland, sibling
EndNote
Accession Number
HRB 4308 (Available)

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