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Home > Recreational drugs and fetal gastroschisis: maternal hair analysis in the peri-conceptional period and during pregnancy.

Morrison, John J and Chitty, Lynn S and Peebles, Donald and Rodeck, Charles H (2005) Recreational drugs and fetal gastroschisis: maternal hair analysis in the peri-conceptional period and during pregnancy. British Journal of Obstetrics and Gynaecology , 112 , (8) , pp. 1022-1025.

The objective of this study was measure individual recreational drug groups in maternal hair samples timed for the period of conception and different stages of pregnancy in expectant mothers with a diagnosis of fetal gastrochisis using a prospective observational study. The setting was a tertiary level Fetal Medicine Unit in a University teaching hospital. The sample population was a group of pregnant wome with a diagnosis of fetal gastrochisis (n=220 and a control group of women (n=25) with a normal fetus. Hair samples were cut from the vertex of the head of expectant mothers witha diagnosis of fetal gastroschisis and a matched control group in whom the fetus was normal. The samples were analysied by enzyme-linked immunosorbent assay (ELISA) for individual drug groups. Confirmatory tests using gas chromotography with mass spectromtry (GCMS) were used. Presence of recreational drug compounds in hair smaples was used as the main outcome measure. In the group with fetal gastrocchisis there were four proven positive cases for recrational druga abuse (!%) and there were none in the control group. The incidence of recreational drug use in the peri-conceptual period and the first trimester by expectant mothers with a diagnosis of fetal gastrochisis is 18%. This association may be linked to the recent increase of grastrochisis among younger mothers.


Item Type
Article
Date
August 2005
Call No
EE20.4.2., VH4.2
Page Range
pp. 1022-1025
Publisher
Wiley-Blackwell
Volume
112
Number
8
EndNote
Accession Number
HRB 2956 (Not in collection)
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