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Home > The molecular epidemiology of human immunodeficiency virus type 1 in six cities in Britain and Ireland.

Brown, AJ Leigh and Lobidel, D and Wade, CM and Rebus, S and Phillips, AN and Brettle, RP and France, AJ and Leen, CS and McMenamin, J and McMillan, A and Maw, RD and Mulcahy, Fiona and Robertson, JR and Sankar, KN and Scott, G and Wyld, R and Peutherer, JF (1997) The molecular epidemiology of human immunodeficiency virus type 1 in six cities in Britain and Ireland. Virology, 235, (1), pp. 166-177.

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The authors sequenced the p17 coding regions of the gag gene from 211 patients infected either through injecting drug use (IDU) or by sexual intercourse between men from six cities in Scotland, N. England, N. Ireland, and the Republic of Ireland. All sequences were of subtype 5. Phylogenetic analysis revealed substantial heterogeneity in the sequences from homosexual men. In contrast, sequence from over 80% of IDUs formed a relatively tight cluster, distinct both from those of published isolates and of the gay men. There was no large-scale clustering of sequences by city in either risk group, although a number of close associations between pairs of individuals were observed. From the known date of the HIV-1 epidemic among IDUs in Edinburgh, the rate of sequence divergence at synonymous sites is estimated to be about 0.8%. On this basis it has been estimated that the date of divergence of the sequences among homosexual men to be about 1975, which may correspond to the origin of the B subtype epidemic.


Item Type
Article
Publication Type
Irish-related, Open Access, Article
Drug Type
Opioid
Date
July 1997
Page Range
pp. 166-177
Publisher
Elsevier Science
Volume
235
Number
1
Notes
Reprinted from Virology, 235(1) Brown et al, The molecular epidemiology of human immunodeficiency virus type 1 in six cities in Britain and Ireland 1997, with permission from Elsevier
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