Mulcahy, Fiona and Bergin, C and Boyle, Nicola and Barry, Michael and Clarke, Susan and Reynolds, Helen (2002) Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor Lopinavir-Ritonavir. Clinical Infectious Diseases, 34, (8), pp. 1143-1145.
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PDF (Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor Lopinavir-Ritonavir)
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A study was designed to determine the interactions, both clinical and pharmacokinetic, between methadone and lopinavir-ritonavir. Results demonstrated a 36% reduction in the methadone area under the plasma concentration-time curve after the introduction of lopinavir-ritonavir, with no coincident symptoms of opioid withdrawal and no requirement for methadone dose adjustment.
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