Home > Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor Lopinavir-Ritonavir.

Mulcahy, Fiona and Bergin, C and Boyle, Nicola and Barry, Michael and Clarke, Susan and Reynolds, Helen (2002) Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor Lopinavir-Ritonavir. Clinical Infectious Diseases , 34 , (8) , pp. 1143-1145.

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URL: http://www.journals.uchicago.edu/doi/full/10.1086/...

A study was designed to determine the interactions, both clinical and pharmacokinetic, between methadone and lopinavir-ritonavir. Results demonstrated a 36% reduction in the methadone area under the plasma concentration-time curve after the introduction of lopinavir-ritonavir, with no coincident symptoms of opioid withdrawal and no requirement for methadone dose adjustment.


Item Type:Article
Date:2002
Page Range:pp. 1143-1145
Publisher:University of Chicago Press
Volume:34
Number:8
EndNote:View
Subjects:B Substances > Opioids (opiates) > Opioid product > Methadone
HJ Treatment method > Substance disorder treatment method > Substance replacement method (substitution)
T Demographic characteristics > Intravenous / injecting drug user
VA Geographic area > Europe > Ireland

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