Home > High rate of Human T Lymphotropic Virus Type IIa infection in HIV 1-infected intravenous drug abusers in Ireland.

Egan, John Fergal and O'Leary, Bronagh and Lewis, Martha J and Mulcahy, Fiona and Sheehy, N and Hasegawa, H and Fitzpatrick, Fidelma and O'Connor, JJ and O'Riordan, Joan and Hall, WW (1999) High rate of Human T Lymphotropic Virus Type IIa infection in HIV 1-infected intravenous drug abusers in Ireland. AIDS Research and Human Retroviruses , 15 , (8) , pp. 699-705.

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This study investigated HTLV-II infections in a cohort of HIV-I-infected intravenous drug users (IVDAs)(n=103)in Dublin. Serological and molecular analyses have demonstrated that 15 (14.6%) were infected with HTLV-II, which is the highest rate of infection so far documented in Europe, and is equivalent to that in urban areas of the United States. Restriction fragment length polymorphism (RFLP) analysis of the env region of the provirus revealed only HTLV-IIa infection. There was no evidence of HTLV-IIb subtype infection. Phlyogenetic analysis of the nucleotide sequences of the long terminal repeat (LTR) confirmed infection with the HTLVE-IIa subtype, and the demonstrated that the viruses clustered closely with HTLV-IIa isolates from North American IVDAs. Previous observations that IVDAs in southern Europe appear to be infected predominantly with the HTLV-IIb sub-type, along with the present report and evidence that the IVDAs in Sweden are infected with HTLV-IIa subtype, suggest different origins of HTLV-II infection in Europe.


Item Type:Article
Date:1999
Page Range:pp. 699-705
Publisher:Mary Ann Liebert Inc
Volume:15
Number:8
EndNote:View
Related URLs:
Subjects:T Demographic characteristics > Intravenous / injecting drug user
G Health and disease > State of health > Physical health
G Health and disease > Disorder by cause > Communicable disease > HIV infection
J Health care, prevention and rehabilitation > Health-related prevention > Health information and education > Communicable disease control

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