This EUDA Precursor Assessment Report examines the evidence on 2-bromo-4′-chloropropiophenone, evaluating its licit use in the EU and the extent of its use in illicit production.

2-Bromo-4′-chloropropiophenone is a chemical precursor used for the production of 4-CMC (Clephedrone or 4-chloromethcathinone) - a synthetic cathinone stimulant drug that has been present in the drug market in the European Union (EU) since at least 2014. 4-CMC has been under international control since 2020. In the period 2014-2023 seizures of 4-CMC in the EU have been close to an average of 300 kilograms per year. However, from additional sources, it appears that the seizures in 2023 could have reached over 7.5 tonnes.