Systematic methods were used to identify, extract and critically appraise reviews that used systematic methods from published and grey literature since 2014 on harm reduction and psychosocial interventions among adults who met the diagnostic criteria of cocaine use disorder, sought treatment for cocaine dependence or used cocaine (in any form and all methods of consumption) as at least one of their substances. Citations from clinical trial registries were identified from the last 10 years, but only those in the last 5 years were included on emerging research for new interventions. We included all interventions and outcomes of harm and/or benefit (including abstinence, reduction in cocaine use and craving, reduction in healthharming behaviours, retention in treatment, adverse events, mental wellbeing).