Home > The impact of substance use disorder and drug transfer into breast milk: implications for maternal and infant health.

Yang, Yongzong and Yi, Bofang and Zhang, Tao (2025) The impact of substance use disorder and drug transfer into breast milk: implications for maternal and infant health. Pharmaceutics, 17, (6), 719. https://doi.org/10.3390/pharmaceutics17060719.

External website: https://www.mdpi.com/1999-4923/17/6/719

Breast milk provides significant health benefits to both infants and mothers, offering protection against infections and enhancing cognitive development. This paper examines the complex effects of substance use disorder (SUD) during pregnancy and lactation, focusing on the pharmacokinetics of drug transfer into breast milk. It highlights the mechanisms by which drugs enter milk, emphasizing the roles of passive diffusion and active transport, particularly through breast cancer resistance protein (BCRP). The study explores the impact of various substances on fetal and infant health, with a focus on the relative infant dose (RID) and milk-to-plasma (MP) ratio as key metrics for assessing drug safety in breastfeeding. The findings underscore the need for careful evaluation of maternal drug use during lactation to balance the benefits of breastfeeding with potential risks.


Item Type
Article
Publication Type
International, Open Access, Article
Drug Type
Alcohol, All substances, Cannabis, CNS depressants / Sedatives, CNS stimulants, Cocaine, Opioid, Prescription/Over the counter, Tobacco / Nicotine
Intervention Type
Harm reduction
Date
29 May 2025
Identification #
https://doi.org/10.3390/pharmaceutics17060719
Volume
17
Number
6
EndNote

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