In March 2025, amidst geopolitical tensions, protracted negotiations, and a chaotic voting session at the 68th session of the Commission on Narcotic Drugs (CND), a ground-breaking document was adopted. A new resolution, submitted by Colombia and supported by a broad cross-regional coalition of Member States, agreed to create a “multidisciplinary panel of 19 independent experts” tasked with reviewing “the existing machinery for the international control of narcotic drugs” and providing recommendations to strengthen the system and its implementation. This is a historical, once-in-a-generation opportunity to propose serious changes that further social inclusion, social justice, and “the health and welfare of humankind”. This opportunity must not be wasted. In this advocacy note, IDPC lays out some key considerations and aspirations for the panel, as well as some of the potential pitfalls to avoid, in order to make this review count.