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Home > Prolonged-release opioids: removal of indication for relief of post-operative pain.

Medicines and Healthcare products Regulatory Agency. (2025) Prolonged-release opioids: removal of indication for relief of post-operative pain. MHRA Safety Update, 18, (8),

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External website: https://www.gov.uk/drug-safety-update/prolonged-re...


From the United Kingdom:

The indication for the treatment of post-operative pain has been removed from the licences of all prolonged release opioids due to the increased risk of persistent post-operative opioid use (PPOU) and opioid-induced ventilatory impairment (OIVI).

  1. Advice for Healthcare Professionals
  2. Advice for Healthcare Professionals to Provide to Patients
  3. Background
    1. Review of the benefits and risks of prolonged release opioids after surgery
    2. Post-operative pain prescribing recommendations
    3. Patients at increased risk
  4. Reporting advice
  5. Additional information
    1. References
    2. Stakeholder engagement
Item Type
Article
Publication Type
International, Guideline, Report
Drug Type
Opioid, Prescription/Over the counter
Intervention Type
Harm reduction
Date
March 2025
Corporate Creators
Medicines and Healthcare products Regulatory Agency
Volume
18
Number
8
EndNote
View
Subjects
B Substances > Opioids (opiates) > Opioid product
E Concepts in biomedical areas > Medical substance > Prescription drug (medicine / medication)
J Health care, prevention, harm reduction and treatment > Patient / client care management
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Treatment issues (pain management)
VA Geographic area > Europe > United Kingdom

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