Reece, Albert Stuart and Hulse, Gary Kenneth (2024) Key insights into cannabis-cancer pathobiology and genotoxicity. Addiction Biology, 29, (11), e70003. https://doi.org/10.1111/adb.70003.
External website: https://onlinelibrary.wiley.com/doi/10.1111/adb.70...
Whilst mitochondrial inhibition and micronuclear fragmentation are well established features of the cannabis literature mitochondrial stress and dysfunction has recently been shown to be a powerful and direct driver of micronucleus formation and chromosomal breakage by multiple mechanisms. In turn genotoxic damage can be expected to be expressed as increased rates of cancer, congenital anomalies and aging; pathologies which are increasingly observed in modern continent-wide studies. Whilst cannabinoid genotoxicity has long been essentially overlooked it may in fact be all around us through the rapid induction of aging of eggs, sperm, zygotes, foetus and adult organisms with many lines of evidence demonstrating transgenerational impacts. Indeed this multigenerational dimension of cannabinoid genotoxicity reframes the discussion of cannabis legalization within the absolute imperative to protect the genomic and epigenomic integrity of multiple generations to come.
B Substances > Cannabis / Marijuana
G Health and disease > State of health > Physical health
G Health and disease > Pathologic process > Cancer
G Health and disease > Disease by cause (Aetiology) > Genetic disorder / epigenetic
G Health and disease > Disease by cause (Aetiology) > Foetal, infant, newborn diseases (reproductive effects)
VA Geographic area > Australia and Oceania > Australia
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