Walton, Sara E and Creed, Jennifer and Denn, Max T and Quinter, Alexis D and DeBord, Joshua and Logan, Barry K and Krotulski, Alex J (2024) Desalkylquazepam — NPS Discovery new drug monograph. United States: Center for Forensic Science Research and Education.
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The following information was compiled in August 2024 and is subject to change as new research is conducted and as new information becomes available:
Description: Desalkylquazepam is a novel designer benzodiazepine bearing structural similarity to diclazepam, desalkylgidazepam, phenazepam, and other NPS benzodiazepines. Desalkylquazepam can be used as a precursor in the synthesis of triazolobenzodiazepines. Desalkylquazepam was first detected in May 2024 by our laboratory and was confirmed after acquiring standard reference material.
Sample Source: Canton-Stark County Crime Laboratory (Canton, OH)
Sample Appearance: Blue powder
Pharmacology: No available pharmacological data for desalkylquazepam were discovered during our search. Structurally similar NPS benzodiazepines are active at the GABAA receptor and produce CNS depressant effects.
Toxicology: Desalkylquazepam has not yet been identified in toxicology cases to date at the CFSRE.
Drug Materials: Desalkylquazepam has been detected in one drug material to date at the CFSRE.
Demographics / Geographics: The drug material sample originated from Ohio. Desalkylquazepam was detected alongside NPS opioids (e.g., protonitazene) and adulterants (e.g., xylazine, diphenhydramine).
Legal Status: Desalkylquazepam is not explicitly scheduled in the United States.
Class:Benzodiazepine
Appearance:Blue powder
Formula:C15H10ClFN2S
MW:304.8 [M+]:304 [M+H]+:305.0310
IUPAC:7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepine-2-thione
Report Date:August 28, 2024
B Substances > New (novel) psychoactive substances > Benzodiazepines
E Concepts in biomedical areas > Pharmacology and toxicology
J Health care, prevention, harm reduction and treatment > Risk and needs assessment > Risk assessment
VA Geographic area > United States
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