There is a need for evidence-based guidelines for gamblers who wish to reduce their risk of harm by setting self-directed limits on their gambling. Recognizing this, the Canadian Low-Risk Gambling Guidelines were developed using data from 8 countries to establish the relationship between gambling behaviour and harm. The guidelines include recommended limits on gambling spending as a percentage of income, gambling frequency, and number of types of games played. However, the developers of the LRGG's did not include UK data in their analysis. This study analyzes data from Health Survey England to assess the applicability of the Canadian Low-Risk Gambling Guidelines to gamblers in England. Using HSE data from 2016 to 2018, we generated risk curves for the relationship between 2 dimensions of gambling behaviour-frequency of gambling sessions and number of types of games played-and gambling harm. We defined harm as a score of 1 or above on the Problem Gambling Severity Index. HSE does not include questions on gambling spending, therefore this was not assessed. The relationship observed between frequency and types of gambling and harm among HSE respondents was similar to the risk curves generated for the development of the Canadian LRGG's. Gamblers in England who gambled twice weekly or more, or who played 3 or more types of games, were significantly more likely to experience harm from gambling than those who gambled below these limits. The Canadian LRGG's may potentially be applied to gambling harm reduction efforts in England. More research is needed to determine the acceptability of these guidelines to people who gamble in England.