Pini, Nicolò and Sania, Ayesha and Rao, Shreya and Shuffrey, Lauren C and Nugent, J David and Lucchini, Maristella and McSweeney, Marco and Hockett, Christine and Morales, Santiago and Yoder, Lydia and Ziegler, Katherine and Perzanowski, Matthew S and Fox, Nathan A and Elliott, Amy J and Myers, Michael M and Fifer, William P (2024) In utero exposure to alcohol and tobacco and electroencephalogram power during childhood. JAMA Network Open, 7, e2350528. 10.1001/jamanetworkopen.2023.50528.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Importance: Prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) are risk factors associated with adverse neurobehavioral and cognitive outcomes.
Question: Are prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) associated with brain activity, measured via electroencephalography (EEG), in early and middle childhood?
Findings: In this cohort study of 649 participants ages 4 to 11 years contributing 795 EEG recordings, PAE and PTE were associated with EEG power. PAE was associated with increased low-frequency brain activity, whereas PTE was associated with decreased high-frequency brain activity.
Meaning: These findings support the public health message that any level of alcohol and/or tobacco consumption during pregnancy has a potentially harmful impact on brain development in the offspring.
B Substances > Alcohol
B Substances > Tobacco (cigarette smoking)
E Concepts in biomedical areas > Nervous system physiology (brain, neural)
E Concepts in biomedical areas > Pregnancy
F Concepts in psychology > Cognition / Memory
G Health and disease > Disease by cause (Aetiology) > Foetal, infant, newborn diseases (reproductive effects)
T Demographic characteristics > Child of person who uses substances
VA Geographic area > United States
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