Ding, Chengyi and Ng Fat, Linda and Britton, Annie and Im, Pek Kei and Lin, Kuang and Topiwala, Anya and Li, Liming and Chen, Zhengming and Millwood, Iona Y and Bell, Steven and Mehta, Gautam (2023) Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease. Nature Communications, 14, 8041. https://doi.org/10.1038/s41467-023-43064-x.
External website: https://www.nature.com/articles/s41467-023-43064-x
Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions.
A Substance use and dependence > Effects or consequences
B Substances > Alcohol
G Health and disease > State of health > Physical health
G Health and disease > Disease by cause (Aetiology) > Genetic disorder / epigenetic
G Health and disease > Digestive system disease > Liver disease
J Health care, prevention, harm reduction and treatment > Risk and protective factors > Risk factors
VA Geographic area > International
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