Home > Association between vmPFC gray matter volume and smoking initiation in adolescents.

Xiang, Shitong and Jia, Tianye and Xie, Chao and Cheng, Wei and Chaarani, Bader and Banaschewski, Tobias and Barker, Gareth J and Bokde, Arun L W and Büchel, Christian and Desrivières, Sylvane and Flor, Herta and Grigis, Antoine and Gowland, Penny A and Brühl, Rüdiger and Martinot, Jean-Luc and Martinot, Marie-Laure Paillère and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Poustka, Luise and Hohmann, Sarah and Fröhner, Juliane H and Smolka, Michael N and Vaidya, Nilakshi and Walter, Henrik and Whelan, Robert and Garavan, Hugh and Schumann, Gunter and Sahakian, Barbara J and Robbins, Trevor W and Feng, Jianfeng (2023) Association between vmPFC gray matter volume and smoking initiation in adolescents. Nature Communications, 14, 4684. doi: 10.1038/s41467-023-40079-2.

External website: https://www.nature.com/articles/s41467-023-40079-2

Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

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