Home > Association of cannabis use during adolescence with neurodevelopment.

Albaugh, Matthew D and Ottino-Gonzalez, Jonatan and Sidwell, Amanda and Lepage, Claude and Juliano, Anthony and Owens, Max M and Chaarani, Bader and Spechler, Philip and Fontaine, Nicholas and Rioux, Pierre and Lewis, Lindsay and Jeon, Seun and Evans, Alan and D'Souza, Deepak and Radhakrishnan, Rajiv and Banaschewski, Tobias and Bokde, Arun L W and Quinlan, Erin Burke and Conrod, Patricia and Desrivières, Sylvane and Flor, Herta and Grigis, Antoine and Gowland, Penny and Heinz, Andreas and Ittermann, Bernd and Martinot, Jean-Luc and Paillère Martinot, Marie-Laure and Nees, Frauke and Papadopoulos Orfanos, Dimitri and Paus, Tomáš and Poustka, Luise and Millenet, Sabina and Fröhner, Juliane H and Smolka, Michael N and Walter, Henrik and Whelan, Robert and Schumann, Gunter and Potter, Alexandra and Garavan, Hugh (2021) Association of cannabis use during adolescence with neurodevelopment. JAMA Psychiatry, 78, (9), pp. 1031-1040. doi: 10.1001/jamapsychiatry.2021.1258.

External website: https://jamanetwork.com/journals/jamapsychiatry/fu...

Importance: Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties between cannabis use and adolescent brain development in humans.

Question: To what extent is cannabis use associated with magnetic resonance imaging–measured cerebral cortical thickness development during adolescence?

Findings: In this cohort study, linear mixed-effects model analysis using 1598 magnetic resonance images from 799 participants revealed that cannabis use was associated with accelerated age-related cortical thinning from 14 to 19 years of age in predominantly prefrontal regions. The spatial pattern of cannabis-related cortical thinning was significantly associated with a positron emission tomography–assessed map of cannabinoid 1 receptor availability.

Meaning: Results suggest that cannabis use during middle to late adolescence may be associated with altered cerebral cortical development, particularly in regions rich in cannabinoid 1 receptors.

Item Type
Publication Type
International, Open Access, Article
Drug Type
Intervention Type
Harm reduction
16 June 2021
Identification #
doi: 10.1001/jamapsychiatry.2021.1258
Page Range
pp. 1031-1040
Jama Network

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