In 2018, the National Academy of Medicine’s (NAM’s) Action Collaborative on Countering the U.S. Opioid Epidemic was established to catalyze public, private, and nonprofit stakeholders to develop, curate, and implement multi-sector solutions designed to reduce opioid misuse and improve outcomes for individuals, families, and communities affected by the opioid crisis. The Action Collaborative’s diverse members work together to advance initiatives organized into the following priority areas, which are also the focus of its work groups: health professional education and training; pain management guidelines and evidence standards; prevention, treatment, and recovery services; and research, data, and metrics needs.