Bogenschutz, Michael P and Ross, Stephen and Bhatt, Snehal and Baron, Tara and Forcehimes, Alyssa A and Laska, Eugene and Mennenga, Sarah E and O'Donnell, Kelley and Owens, Lindsey T and Podrebarac, Samantha and Rotrosen, John and Tonigan, J Scott and Worth, Lindsay (2022) Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized clinical trial. JAMA Psychiatry, 79, (10), pp. 953-962. 10.1001/jamapsychiatry.2022.2096.
External website: https://jamanetwork.com/journals/jamapsychiatry/fu...
Importance: Although classic psychedelic medications have shown promise in the treatment of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown.
Question: Does psilocybin-assisted treatment improve drinking outcomes in patients with alcohol use disorder relative to outcomes observed with active placebo medication?
Findings: In this double-blind randomized clinical trial with 93 participants, the percentage of heavy drinking days during 32 weeks of follow-up was significantly lower in the psilocybin group than in the diphenhydramine group.
Meaning: The results in this trial showed that psilocybin administered in combination with psychotherapy produced robust decreases in the percentage of heavy drinking days compared with those produced by active placebo and psychotherapy.
B Substances > Hallucinogens / Psychedelics > Mushrooms (psilocybin)
G Health and disease > Substance use disorder > Alcohol use disorder
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Treatment outcome
HJ Treatment or recovery method > Psychotherapy
VA Geographic area > United States
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