Home > Feasibility of prospectively comparing opioid analgesia with opioid-free analgesia after outpatient general surgery: a pilot randomized clinical trial.

Do, Uyen and El-Kefraoui, Charbel and Pook, Makena and Balvardi, Saba and Barone, Natasha and Nguyen-Powanda, Philip and Lee, Lawrence and Baldini, Gabriele and Feldman, Liane S and Fiore, Julio F and Alhashemi, Mohsen and Antoun, Alen and Barkun, Jeffrey S and Brecht, Krista M and Chaudhury, Prosanto K and Deckelbaum, Dan and Di Lena, Elise and Dumitra, Sinziana and Elhaj, Hiba and Fata, Paola and Fleiszer, David and Fried, Gerald M and Grushka, Jeremy and Kaneva, Pepa and Khwaja, Kosar and Lapointe-Gagner, Maxime and McKendy, Katherine M and Meguerditchian, Ari N and Meterissian, Sarkis H and Montgomery, Haley and Rajabiyazdi, Fateme and Safa, Nadia and Touma, Nawar and Tremblay, Francine (2022) Feasibility of prospectively comparing opioid analgesia with opioid-free analgesia after outpatient general surgery: a pilot randomized clinical trial. JAMA Network Open, 5, (7), e2221430. doi: 10.1001/jamanetworkopen.2022.21430.

External website: https://jamanetwork.com/journals/jamanetworkopen/f...


Importance: The overprescription of opioids to surgical patients is recognized as an important factor contributing to the opioid crisis. However, the value of prescribing opioid analgesia (OA) vs opioid-free analgesia (OFA) after postoperative discharge remains uncertain.

Question: Is it feasible to conduct a randomized clinical trial (RCT) comparing opioid analgesia with opioid-free analgesia after outpatient general surgery?

Findings: In this pilot RCT, 76 patients were randomized 1:1 to receive opioid or opioid-free analgesia after postoperative discharge. The trial proposed was well accepted by the stakeholders involved, including patients and clinicians, and all a priori feasibility criteria were fulfilled.

Meaning: These findings support the feasibility of an RCT to prospectively compare opioid analgesia with opioid-free analgesia after hospital discharge following outpatient general surgery.

Item Type
Article
Publication Type
International, Open Access, Article
Drug Type
Opioid
Intervention Type
Drug therapy
Date
1 July 2022
Identification #
doi: 10.1001/jamanetworkopen.2022.21430
Volume
5
Number
7
EndNote

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