Virtanen, Suvi and Kuja-Halkola, Ralf and Sidorchuk, Anna and Fernández de la Cruz, Lorena and Rück, Christian and Lundström, Sebastian and Suvisaari, Jaana and Larsson, Henrik and Lichtenstein, Paul and Mataix-Cols, David and Latvala, Antti (2022) Association of obsessive-compulsive disorder and obsessive-compulsive symptoms with substance misuse in 2 longitudinal cohorts in Sweden. JAMA Network Open, 5, (6), e2214779. doi: 10.1001/jamanetworkopen.2022.14779.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Question: Do individuals with obsessive-compulsive disorder (OCD) or obsessive-compulsive symptoms have an elevated risk of substance misuse, and if so, to what extent do shared genetic and/or environmental factors account for their association?
Findings: This Swedish cohort study of 6 304 188 individuals from the general population and 9230 individuals in a separate twin cohort found that individuals with an OCD diagnosis had a 3.7-fold elevated risk of any substance misuse outcome. The association of OCD and obsessive-compulsive symptoms with substance misuse was partially attributed to shared genetics.
Meaning: These findings suggest that regular screening for substance use and problems should be included in routine clinical management of patients with OCD.
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