Mintz, Carrie M and Xu, Kevin Y and Presnall, Ned J and Hartz, Sarah M and Levin, Frances R and Scherrer, Jeffrey F and Bierut, Laura J and Grucza, Richard A (2022) Analysis of stimulant prescriptions and drug-related poisoning risk among persons receiving buprenorphine treatment for opioid use disorder. JAMA Network Open, 5, (5), e2211634. doi: 10.1001/jamanetworkopen.2022.11634.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Key Points:
Question: How are use of prescription stimulants associated with treatment outcomes in persons with opioid use disorder (OUD)?
Findings: In this cohort study of 22 946 persons with OUD receiving buprenorphine treatment, stimulant treatment days were associated with 19% increased odds of drug-related poisoning and 36% decreased risk of attrition from buprenorphine treatment.
Meaning: These findings suggest that among persons with OUD who have experienced a drug-related poisoning, stimulant use is associated with a modest increased risk of drug-related poisoning that may be offset by longer duration of buprenorphine treatment, which is associated with protection against overdose.
B Substances > Opioids (opiates) > Opioid product > Buprenorphine / Suboxone
E Concepts in biomedical areas > Medical substance > Prescription drug (medicine / medication)
G Health and disease > Substance use disorder > Drug use disorder > Drug intoxication > Poisoning (overdose)
HJ Treatment or recovery method > Substance disorder treatment method > Substance replacement method (substitution) > Opioid agonist treatment (methadone maintenance / buprenorphine)
VA Geographic area > United States
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