Xu, Kevin Y and Mintz, Carrie M and Presnall, Ned and Bierut, Laura J and Grucza, Richard A (2022) Comparative effectiveness associated with buprenorphine and naltrexone in opioid use disorder and cooccurring polysubstance use. JAMA Network Open, 5, (5), e2211363. doi: 10.1001/jamanetworkopen.2022.11363.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Question: What is the prevalence and comparative effectiveness associated with buprenorphine and naltrexone in individuals with opioid use disorder (OUD) and cooccurring substance use disorders (SUDs)?
Findings: This comparative effectiveness study evaluated 179 280 individuals with OUD using insurance claims. Individuals with OUD and co-occurring SUDs were less likely to receive buprenorphine and more likely to receive extended-release naltrexone than peers without polysubstance use; buprenorphine and extended-release naltrexone were comparable in their protective associations with drug-related poisonings in both populations.
Meaning: These findings suggest that individuals with cooccurring SUDs were less likely to receive buprenorphine despite buprenorphine’s association with protecting against overdose in this population.
B Substances > Opioids (opiates) > Opioid product > Buprenorphine / Suboxone
G Health and disease > Substance use disorder (addiction) > Multiple substance use (Poly-drug /Poly-substance)
G Health and disease > Substance use disorder (addiction) > Drug use disorder > Drug intoxication > Poisoning (overdose)
HJ Treatment or recovery method > Substance disorder treatment method > Substance disorder drug therapy (pharmacological treatment)
HJ Treatment or recovery method > Substance disorder treatment method > Substance replacement method (substitution) > Opioid agonist treatment (methadone maintenance / buprenorphine)
HJ Treatment or recovery method > Treatment outcome
J Health care, prevention, harm reduction and treatment > Treatment and maintenance > Treatment factors
VA Geographic area > United States
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