Home > Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning.

Owens, Max M and Albaugh, Matthew D and Allgaier, Nicholas and Yuan, Dekang and Robert, Gabriel and Cupertino, Renata B and Spechler, Philip A and Juliano, Anthony and Hahn, Sage and Banaschewski, Tobias and Bokde, Arun L W and Desrivières, Sylvane and Flor, Herta and Grigis, Antoine and Gowland, Penny and Heinz, Andreas and Brühl, Rüdiger and Martinot, Jean-Luc and Martinot, Marie-Laure Paillère and Artiges, Eric and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Lemaitre, Herve and Paus, Tomáš and Poustka, Luise and Millenet, Sabina and Fröhner, Juliane H and Smolka, Michael N and Walter, Henrik and Whelan, Robert and Mackey, Scott and Schumann, Gunter and Garavan, Hugh (2022) Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning. Translational Psychiatry, 12, 188. doi: 10.1038/s41398-022-01956-4.

External website: https://www.nature.com/articles/s41398-022-01956-4

While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempts to identify probable causal relationships in correlational data using conditional probabilities to estimate directional associations between a set of interrelated variables. In this study, we employed BCN modeling in 637 adolescents from the IMAGEN study who were cannabis naïve at age 14 to provide evidence that the accelerated prefrontal cortical thinning found previously in adolescent cannabis users by Albaugh et al. [1] is a result of cannabis use causally affecting neurodevelopment.

BCNs incorporated data on cannabis use, prefrontal cortical thickness, and other factors related to both brain development and cannabis use, including demographics, psychopathology, childhood adversity, and other substance use. All BCN algorithms strongly suggested a directional relationship from adolescent cannabis use to accelerated cortical thinning. While BCN modeling alone does not prove a causal relationship, these results are consistent with a body of animal and human research suggesting that adolescent cannabis use adversely affects brain development.

Item Type
Publication Type
International, Open Access, Article
Drug Type
Intervention Type
Harm reduction
6 May 2022
Identification #
doi: 10.1038/s41398-022-01956-4
Nature Publishing Group

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