Home > Impact of nicotine on cognition in patients with schizophrenia: a narrative review.

Spasova, Violeta and Mehmood, Saqib and Minhas, Amjad and Azhar, Rabia and Anand, Silpa and Abdelaal, Sondous and Sham, Sunder and Chauhan, Tabssum M and Dragas, David (2022) Impact of nicotine on cognition in patients with schizophrenia: a narrative review. Cureus, 14, (4), e24306. doi: 10.7759/cureus.24306.

External website: https://www.cureus.com/articles/69510-impact-of-ni...

Nicotine is the psychoactive component given tobacco has several main components and acts as an agonist for nicotinic acetylcholine receptors (nAChRs) in the nervous system. Although the ligand-gated cation channels known as nAChRs are found throughout the nervous system and body, this review focuses on neuronal nAChRs. Individuals with psychiatric diseases such as schizophrenia, comorbid substance use disorders, attention-deficit hyperactivity disorder, major depression, and bipolar disorder have increased rates of smoking. These psychiatric disorders are associated with various cognitive deficits, including working memory, deficits in attention, and response inhibition functions. The cognitive-enhancing effects of nicotine may be particularly relevant predictors of smoking initiation and continuation in this comorbid population. Individuals with schizophrenia make up a significant proportion of smokers. Literature suggests that patients smoke to alleviate cognitive deficiencies due to the stimulating effects of nicotine. This narrative review examines the role of nicotine on cognition in schizophrenia.

Item Type
Publication Type
International, Open Access, Review, Article
Drug Type
Tobacco / Nicotine
Intervention Type
Harm reduction
April 2022
Identification #
doi: 10.7759/cureus.24306

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