Home > MicroRNAs in methamphetamine-induced neurotoxicity and addiction.

Deng, Bi and Zhang, Zhirui and Zhou, Huixuan and Zhang, Xinran and Niu, Shuliang and Yan, Xisheng and Yan, Jie (2022) MicroRNAs in methamphetamine-induced neurotoxicity and addiction. Frontiers in Pharmacology, 13, 875666. doi: 10.3389/fphar.2022.875666.

External website: https://www.frontiersin.org/articles/10.3389/fphar...

Methamphetamine (METH) abuse remains a significant public health concern globally owing to its strong addictive properties. Prolonged abuse of the drug causes irreversible damage to the central nervous system. To date, no efficient pharmacological interventions are available, primarily due to the unclear mechanisms underlying METH action in the brain. Recently, microRNAs (miRNAs) have been identified to play critical roles in various cellular processes. The expression levels of some miRNAs are altered after METH administration, which may influence the transcription of target genes to regulate METH toxicity or addiction. This review summarizes the miRNAs in the context of METH use, discussing their role in the reward effect and neurotoxic sequelae. Better understanding of the molecular mechanisms involved in METH would be helpful for the development of new therapeutic strategies in reducing the harm of the drug.

Item Type
Publication Type
International, Open Access, Review, Article
Drug Type
CNS stimulants
Intervention Type
Treatment method
Identification #
doi: 10.3389/fphar.2022.875666
Frontiers Media

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