O'Reilly, Eve M and Cosgrave, Joanne M and Gallagher, William M and Perry, Antoinette S (2022) Plant-derived cannabinoids as anticancer agents. Trends in Cancer, 8, (5), pp. 350-357. doi: 10.1016/j.trecan.2022.01.017.
Substantial preclinical evidence demonstrates the antiproliferative, cytotoxic, and antimetastatic properties of plant-derived cannabinoids (phytocannabinoids) such as cannabidiol and tetrahydrocannabinol. The cumulative body of research into the intracellular mechanisms and phenotypic effects of these compounds supports a logical, judicious progression to large-scale phase II/III clinical trials in certain cancer types to truly assess the efficacy of phytocannabinoids as anticancer agents.
B Substances > Cannabis product / compounds (Plant-derived cannabinoids) > Cannabinol / Cannabidiol (CBD oil)
E Concepts in biomedical areas > Medical substance > Medical / medicinal cannabis
G Health and disease > Pathology > Cancer
VA Geographic area > Europe > Ireland
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