Home > Plant-derived cannabinoids as anticancer agents.

O'Reilly, Eve M and Cosgrave, Joanne M and Gallagher, William M and Perry, Antoinette S (2022) Plant-derived cannabinoids as anticancer agents. Trends in Cancer, 8, (5), pp. 350-357. doi: 10.1016/j.trecan.2022.01.017.

Substantial preclinical evidence demonstrates the antiproliferative, cytotoxic, and antimetastatic properties of plant-derived cannabinoids (phytocannabinoids) such as cannabidiol and tetrahydrocannabinol. The cumulative body of research into the intracellular mechanisms and phenotypic effects of these compounds supports a logical, judicious progression to large-scale phase II/III clinical trials in certain cancer types to truly assess the efficacy of phytocannabinoids as anticancer agents.

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