Home > Nanoparticle delivery systems for substance use disorder.

Kasina, Vishal and Mownn, Robert J and Bahal, Raman and Sartor, Gregory C (2022) Nanoparticle delivery systems for substance use disorder. Neuropsychopharmacology, doi: 10.1038/s41386-022-01311-7.

External website: https://www.nature.com/articles/s41386-022-01311-7

Innovative breakthroughs in nanotechnology are having a substantial impact in healthcare, especially for brain diseases where effective therapeutic delivery systems are desperately needed. Nanoparticle delivery systems offer an unmatched ability of not only conveying a diverse array of diagnostic and therapeutic agents across complex biological barriers, but also possess the ability to transport payloads to targeted cell types over a sustained period. In substance use disorder (SUD), many therapeutic targets have been identified in preclinical studies, yet few of these findings have been translated to effective clinical treatments. The lack of success is, in part, due to the significant challenge of delivering novel therapies to the brain and specific brain cells. In this review, we evaluate the potential approaches and limitations of nanotherapeutic brain delivery systems. We also highlight the examples of promising strategies and future directions of nanocarrier-based treatments for SUD.

Item Type
Publication Type
International, Open Access, Review, Article
Drug Type
All substances
Intervention Type
Treatment method
28 March 2022
Identification #
doi: 10.1038/s41386-022-01311-7
Nature Publishing Group

Repository Staff Only: item control page