McCabe, Sean Esteban and Schulenberg, John E and Schepis, Ty S and McCabe, Vita V and Veliz, Philip T (2022) Longitudinal analysis of substance use disorder symptom severity at age 18 years and substance use disorder in adulthood. JAMA Network Open, 5, (4), e225324. doi: 10.1001/jamanetworkopen.2022.5324.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Question: What are the long-term sequelae of substance use disorder (SUD) symptoms from adolescence through adulthood?
Findings: In this national multicohort study of 5317 individuals followed from ages 18 to 50 years, the majority of adolescents with the most severe SUD symptoms had 2 or more SUD symptoms in adulthood. Most adults using prescribed opioids, sedatives, or tranquilizers had multiple SUD symptoms during adolescence.
Meaning: These findings suggest that most adolescents with severe SUD symptoms do not transition out of symptomatic substance use over a 32-year period, and prescribers must be aware that many adults prescribed controlled substances had SUD symptoms during adolescence and require careful assessment.
A Substance use and dependence > Personal history of substance use (pathway)
E Concepts in biomedical areas > Medical substance > Prescription drug (medicine / medication)
G Health and disease > Substance use disorder
G Health and disease > Substance use disorder > Drug use disorder
J Health care, prevention, harm reduction and treatment > Risk and protective factors > Risk factors
J Health care, prevention, harm reduction and treatment > Patient / client care management
T Demographic characteristics > Adolescent / youth (teenager / young person)
T Demographic characteristics > Young adult
VA Geographic area > United States
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