Kleerekooper, Iris and Chua, Sharon and Foster, Paul J and Trip, S Anand and Plant, Gordon T and Petzold, Axel and Patel, Praveen (2022) Associations of alcohol consumption and smoking with disease risk and neurodegeneration in individuals with multiple sclerosis in the United Kingdom. JAMA Network Open, 5, (3), e220902. doi: 10.1001/jamanetworkopen.2022.0902.
External website: https://jamanetwork.com/journals/jamanetworkopen/f...
Question: How are modifiable risk factors such as alcohol consumption, smoking, and obesity associated with disease risk and neurodegeneration in individuals with multiple sclerosis (MS)?
Findings: This cross-sectional study of 71 981 individuals in the United Kingdom found that high alcohol consumption was associated with retinal features indicative of more severe neurodegeneration, whereas smoking was associated with higher odds of being diagnosed with MS.
Meaning: These findings suggest that current recommendations for the general population regarding smoking and moderating alcohol consumption may be particularly relevant for individuals who have been diagnosed with MS or who are at risk for the disease.
A Substance use and dependence > Effects or consequences
B Substances > Alcohol
B Substances > Tobacco (cigarette smoking)
E Concepts in biomedical areas > Nervous system physiology (brain, neural)
G Health and disease > State of health > Physical health
VA Geographic area > Europe > United Kingdom
Repository Staff Only: item control page