Toronto continues to experience a devastating increase in fatal and non-fatal overdoses, with over 1500 people who have died from opioid-related overdose in the past five years. To respond, harm reduction workers have been at the forefront of designing and implementing overdose response and prevention strategies. There is an urgent need to understand how experiencing, witnessing, and responding to overdose in the current crisis is affecting harm reduction workers. This report summarizes the impact of overdoses and overdose-related loss on harm reduction workers and strategies to address their support needs. We have conducted this preliminary analysis to help inform the development of interventions and strategies to support the health and well-being of harm reduction workers in Toronto.