Home > Psychedelic therapy's transdiagnostic effects: a research domain criteria (RDoC) perspective.

Kelly, John R and Gillan, Claire M and Prenderville, Jack and Kelly, Clare and Harkin, Andrew and Clarke, Gerard and O'Keane, Veronica (2021) Psychedelic therapy's transdiagnostic effects: a research domain criteria (RDoC) perspective. Frontiers in Psychiatry, 12, p. 800072. doi: 10.3389/fpsyt.2021.800072.

External website: https://www.frontiersin.org/articles/10.3389/fpsyt...

Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining psychopharmacology and psychological support, offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and/or maladaptive habitual patterns of emotion, cognition and behavior, notably, depression (MDD), treatment resistant depression (TRD) and addiction disorders, but perhaps also anxiety disorders, obsessive-compulsive disorder (OCD), Post-Traumatic Stress Disorder (PTSD) and eating disorders. Despite the emergent transdiagnostic evidence, the specific clinical dimensions that psychedelics are efficacious for, and associated underlying neurobiological pathways, remain to be well-characterized. To this end, this review focuses on pre-clinical and clinical evidence of the acute and sustained therapeutic potential of psychedelic therapy in the context of a transdiagnostic dimensional systems framework. Focusing on the Research Domain Criteria (RDoC) as a template, we will describe the multimodal mechanisms underlying the transdiagnostic therapeutic effects of psychedelic therapy, traversing molecular, cellular and network levels. These levels will be mapped to the RDoC constructs of negative and positive valence systems, arousal regulation, social processing, cognitive and sensorimotor systems. In summarizing this literature and framing it transdiagnostically, we hope we can assist the field in moving toward a mechanistic understanding of how psychedelics work for patients and eventually toward a precise-personalized psychedelic therapy paradigm.

Item Type
Publication Type
International, Open Access, Review, Article
Drug Type
CNS stimulants
Intervention Type
Drug therapy, Treatment method
17 December 2021
Identification #
doi: 10.3389/fpsyt.2021.800072
Page Range
p. 800072
Frontiers Research Foundation

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