Home > Effect of pharmacological manipulations on Arc function.

Yakout, Dina W and Shree, Nitheyaa and Mabb, Angela M (2021) Effect of pharmacological manipulations on Arc function. Current Research in Pharmacology and Drug Discovery, 2, p. 100013. doi: 10.1016/j.crphar.2020.100013.

External website: https://www.sciencedirect.com/science/article/pii/...

Activity-regulated cytoskeleton-associated protein (Arc) is a brain-enriched immediate early gene that regulates important mechanisms implicated in learning and memory. Arc levels are controlled through a balance of induction and degradation in an activity-dependent manner. Arc further undergoes multiple post-translational modifications that regulate its stability, localization and function. Recent studies demonstrate that these features of Arc can be pharmacologically manipulated. In this review, we discuss some of these compounds, with an emphasis on drugs of abuse and psychotropic drugs. We also discuss inflammatory states that regulate Arc.

Repository Staff Only: item control page