Home > The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality.

Karlsen, Tom H and Sheron, Nick and Zelber-Sagi, Shira and Carrieri, Patrizia and Dusheiko, Geoffrey and Bugianesi, Elisabetta and Pryke, Rachel and Hutchinson, Sharon J and Sangro, Bruno and Martin, Natasha K and Cecchini, Michele and Dirac, Mae Ashworth and Belloni, Annalisa and Serra-Burriel, Miquel and Ponsioen, Cyriel Y and Sheena, Brittney and Lerouge, Alienor and Devaux, Marion and Scott, Nick and Hellard, Margaret and Verkade, Henkjan J and Sturm, Ekkehard and Marchesini, Giulio and Yki-Järvinen, Hannele and Byrne, Chris D and Targher, Giovanni and Tur-Sinai, Aviad and Barrett, Damon and Ninburg, Michael and Reic, Tatjana and Taylor, Alison and Rhodes, Tim and Treloar, Carla and Petersen, Claus and Schramm, Christoph and Flisiak, Robert and Simonova, Marieta Y and Pares, Albert and Johnson, Philip and Cucchetti, Alessandro and Graupera, Isabel and Lionis, Christos and Pose, Elisa and Fabrellas, Núria and Ma, Ann T and Mendive, Juan M and Mazzaferro, Vincenzo and Rutter, Harry and Cortez-Pinto, Helena and Kelly, Deirdre and Burton, Robyn and Lazarus, Jeffrey V and Ginès, Pere and Buti, Maria and Newsome, Philip N and Burra, Patrizia and Manns, Michael P (2021) The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality. Lancet, https://doi.org/10.1016/s0140-6736(21)01701-3.


Liver disease is a leading cause of years of working life lost in Europe, second only to ischaemic heart disease. One of the continuing problems has been the focus on end-stage liver disease and its complications – cirrhosis and cancer.
The Commission argues that there should be a fundamental change to prevent the development of advanced liver disease by embracing simple methods for early identification of progressive liver fibrosis together with strategies for disease prevention.


Underserved and marginalised communities, including children, require particular attention, and the significant stigma associated with liver disease needs tackling including the removal of stigma-associated terms in medical nomenclature.


Policy actions for marketing, pricing, and taxation of alcohol and unhealthy foods are of vital importance for supporting and preserving liver health.

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